Profiting from Genetic Disease Resistance

January 28, 2013 05:54 PM
Profiting from Genetic Disease Resistance

Disease can be costly, but genetic testing for immune response could be profitable

Sick cows are unprofitable cows. It’s an easy equation to understand. If a cow can’t milk because she’s suffering from mastitis or is too lame, then she won’t contribute much to your bottom line.
But what if there was a way to find those cattle that are genetically superior at fending off disease?
For nearly three decades, Bonnie Mallard, immunogenetist at the University of Guelph in Canada, has researched ways to help livestock producers breed those types of healthy animals, particularly dairy cattle. She believes genetic selection for immune response should improve efficiency of disease management, but it comes with some challenges.

“Disease resistance is hard to improve genetically because for the most part, the heritability of these traits is low,” Mallard says. “That means the genetic progress is relatively slow.”

Mallard cautions against selecting animals based on resistance to a single disease. An example would be
improving mastitis resistance in dairy cows at the expense of greater exposure to tuberculosis. “If we do this right, our hypothesis was we should be able to achieve overall resistance to a broad range of pathogens,” Mallard adds.

To complicate matters, however, disease recording is poor. That’s particularly true in countries with large cow populations. Many dairy producers and veterinarians record disease, but they may not do it the same way. And because they don’t, it’s not easy to sort the data.

Uniform data reporting is critical: “If you want to look at traits associated with disease resistance, you have got to have quality data,” Mallard adds.

Through research, Mallard and members of the staff at the University of Guelph were able to create a test that measured immune response in dairy cattle. It was modeled around a similar procedure they had developed for swine.

The test looks at two features of the Adaptive Immunity System: cell-mediated immune response (CMIR) and antibody-mediated immune response (AMIR). CMIR fights intracellular infections—pathogens such as viruses that cannot survive or replicate without being inside the host cell or special types of bacteria such as mycobacterium (i.e. Johnes Disease or tuberculosis). AMIR fights extra-cellular infections. This system deals with many types of bacteria most important in fighting mastitis.

“There are about 2,000 genes that control disease resistance or immune response in mammals,” Mallard says. “It is definitely a highly complex trait with many genes to consider.”

The High Immune Responder test requires three farm visits during a 15-day period, but luckily, it only has to be done once in an animal’s life and can be performed at two months of age. On the first day, background measurements are taken, and the animal is immunized. Two weeks later, the immune system is responding to the immunizations, so the magnitude of the response can be measured. Blood samples are taken for analysis to the lab, and a booster is given to the cell mediated arm of the immune system. The following day, a skin thickness measurement is performed.

“Now the immune response traits that we look at—we’ve selected them so that they have heritability at about 25%,” Mallard says. To put that 25% heritability in context, production traits have 25% to 35% heritability.
“The genetic improvement that has been made in those production traits will be in the same magnitude
as what you’d anticipate you would make with the immune response traits that we selected to put in our
index,” Mallard adds.

When the results are in, they identify cattle with a greater ability to resist a variety of infectious diseases. These animals are known as high-immune responders.

A research project conducted at North Florida Holsteins, Bell, Fla., tested 700 cows. The high responders in the herd were found to have reduced incidence of mastitis by 27%, metritis by 17% and retained placenta by 32% compared to the average cows in the herd.

“Of the herds that we’ve looked at to date, they’re in that range of 19% to 30% less incidence of disease,” Mallard says.

Another study looked at mastitis in cows on 58 dairies across Canada for five years. High-immune responders had a 17% incidence of mastitis compared to 28% for average responders and 31% in low immune responders. Not only did low responders have the highest incidence of mastitis, they also had the most severe mastitis, Mallard notes.

Selecting for cows that are high immune responders allows for better response to vaccines, higher quality
colostrum, lower culling rates and reduced lameness.

“We’re just starting to collect data on hoof health,” Mallard says. “High AMIR cows have less infectious digital dermatitis, a major cause of lameness. The high CMIR cows tended to have less interdigital hyperplasia.”
Economically, cows identified to be high immune responders generate higher levels of returns to producers. “The minimal benefit a producer can expect from a high responder cow versus an average cow is an additional $124 per year per cow,” Mallard adds. “That’s the absolute guaranteed minimum.”
Getting these genetic health benefits out to producers across the globe has been the latest development. In 2013, Semex worked with the University of Guelph to license use of this technology in their sires.
All marketable and young genomic bulls at Semex are tested. Then, the top 10% are selected and marketed under the label Immunity . Those bulls have to be high in both the CMIR and AMIR scores.
“It’s really important to get this application easily accessible to producers worldwide,” Mallard says. “That will come not through going into the herd and doing our phenotypic tests, which is fairly labor
intensive, but through seeing if we can develop a genomics test.”

There have been some initial studies done to determine the DNA markers. The focus has been on Chromosome 23, which was identified because it contains Bovine Major Histocompatibility Complex (BoLA), a gene cluster responsible for regulating immunity in cattle.

“We believe that eventually this is going to change the way producers select and manage the health of their herds,” Mallard says. 

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